Lesson 24

Key points:

1. Viral infections (respiratory viruses: COVID-19, influenza, measles, rubella, chickenpox, mumps, polio, mononucleosis): clinical and morphological manifestations.

2. Rickettsioses: spotted fever, epidemic typhus. Classification, pathomorphology.

3. Acquired immunodeficiency syndrome (AIDS): morphogenesis, clinical and morphological characteristics. AIDS-associated diseases: opportunistic infections, tumors. Complications, causes of death. Pathomorphological changes in HIV infection

4. Rabies: morphological characteristics, causes of death.

5. Latent viral neuroinfections and prion diseases (Kuru, Creutzfeldt-Jakob disease, prion diseases in animals): morphological characteristics.

6. General characteristics of the infectious process: entry port of infection, primary infectious complex, spread and dissemination, ways of transmission of infectious diseases. Morphological variants of local and general reactions at infections: with participation of neutrophils (purulent inflammation); involving lymphocytes and macrophages (mononuclear infiltration and granulomatous inflammation); viral infection response (cytopathic) with the advantage of necrotic local reaction.


Sources:
1. Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015. P.69-99, 186-265.
2. Kumar, Vinay, Abul K Abbas, Jon C Aster, and Stanley L. 1915-2003 Robbins. RobbinsBasic Pathology. Tenth edition. Philadelphia, PA: Elsevier/Saunders, 2018. P. 57-87, 121-184
3. Klatt, Edward C. Robbins and Cotran Atlas of Pathology. Third edition. Philadelphia, PA: ElsevierSaunders, 2015.
4. Klatt, Edward C., and Vinay Kumar. Robbins and Cotran Review of Pathology. Fourth edition. Philadelphia, PA: Elsevier Saunders, 2015. P.18-30, 57-75
5. Harsh Mohan. Essential Pathology for Dental Students.Fourth edition. Jaypee Brothers,Medical Publishers Pvt. Limited, 2011. P.109-129