Lesson 10
Molecular and morphological basics of the immune response. Immune system in the prenatal and postnatal periods. Immune pathology: amyloidosis, hypersensitivity reactions, graft rejection. Immunodeficiency. Autoimmune diseases
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Key points:
1. Changes in the thymus caused at the immune disorders. Age involution and accidental transformation. Congenital diseases of the thymus: hypoplasia, dysplasia, thymomegaly.
2. The body's immune response to the antigens. Immunological tolerance.
3. Basics of the immune response. Humoral immunity. Cellular immunity. Immunological hypersensitivity: Morphological characteristics of anaphylaxy; antibody-mediated hypersensitivity; immunocomplex hypersensitivity; delayed-type hypersensitivity.
4. Autoimmune diseases: clinical and morphological characteristics.
5. Amyloidosis: classification, morphological characteristics.
6. Immunodeficiency: general clinical and morphological characteristics of primary and secondary immune deficiency. Immune deficiency syndromes.
7. Pathomorphological characteristics of changes in the organ at the early and late stages of transplantation.
Sources:
1. Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015. P.69-99, 186-265.
2. Kumar, Vinay, Abul K Abbas, Jon C Aster, and Stanley L. 1915-2003 Robbins. Robbins Basic Pathology. Tenth edition. Philadelphia, PA: Elsevier/Saunders, 2018. P. 57-87, 121-184
3. Klatt, Edward C. Robbins and Cotran Atlas of Pathology. Third edition. Philadelphia, PA: Elsevier Saunders, 2015.
4. Klatt, Edward C., and Vinay Kumar. Robbins and Cotran Review of Pathology. Fourth edition. Philadelphia, PA: Elsevier Saunders, 2015. P.18-30, 57-75
5. Harsh Mohan. Essential Pathology for Dental Students.Fourth edition. Jaypee Brothers,Medical Publishers Pvt. Limited, 2011. P.137-159
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