Lesson 11

Regeneration. Structural basics of physiological adaptation of organs and cells. Morphology of cell adaptation. Compensatory and adaptive processes

Key points:

1. Definition of "adaptation" and "compensation".

2. Definition of hypertrophy and hyperplasia, their mechanisms and types.

3. Working hypertrophy of the heart: causes, mechanism of development, gross and microscopic changes in the compensatory stage and in the stage of decompensation, consequences.

4. Definition of atrophy, its types by origin and prevalence. General atrophy: causes, morphological characteristics. Types of local atrophy, examples, morphology.

5. Metaplasia: definition, the most common localization, causes, morphology, consequences.

6. Dysplasia: causes, morphological nature, consequences.

7. Repair and regeneration: definitions, types and biological significance, association with inflammation. Morphogenesis of repair.

8. Regeneration of certain types of tissues and organs. Repair of connective tissue. Granulation tissue: morphological characterization of its stages. Types of wound healing.

9. Dysregeneration: morphological characterization of hyperregeneration and hypo-regeneration of injured tissues.

Sources:

1. Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015. P.15-29, 34-38, 66, 100-112

2. Kumar, Vinay, Abul K Abbas, Jon C Aster, and Stanley L. 1915-2003 Robbins. Robbins Basic Pathology. Tenth edition. Philadelphia, PA: Elsevier/Saunders, 2018. P.19-28, 48-51, 54, 87-94

3. Klatt, Edward C. Robbins and Cotran Atlas of Pathology. Third edition. Philadelphia, PA: Elsevier Saunders, 2015.

4. Klatt, Edward C., and Vinay Kumar. Robbins and Cotran Review of Pathology. Fourth edition. Philadelphia, PA: Elsevier Saunders, 2015. P.18-30

5. Harsh Mohan. Essential Pathology for Dental Students.Fourth edition. Jaypee Brothers,Medical Publishers Pvt. Limited, 2011. P. 221-227, 129-137