extracellular accumulations

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Morphological stromal changes in respone to injury (stromal-vascular degenerations). Morphology of proteids (hyalinosis) and lipids accumulations. Body depletion

• Preparation materials:

1. Workbook, part I, pp. 10-11.

2. Sources:

1. Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015. P.7-64

2. Kumar, Vinay, Abul K Abbas, Jon C Aster, and Stanley L. 1915-2003 Robbins. Robbins Basic Pathology. 10th ed. Philadelphia, PA: Elsevier/Saunders, 2018. P.1-33, 51

3. Klatt, Edward C. Robbins and Cotran Atlas of Pathology. Third edition. Philadelphia, PA: Elsevier Saunders, 2015.

4. Klatt, Edward C., and Vinay Kumar. Robbins and Cotran Review of Pathology. Fourth edition. Philadelphia, PA: Elsevier Saunders, 2015. P.3-17

5. Harsh Mohan. Essential Pathology for Dental Students.Fourth edition. Jaypee Brothers,Medical Publishers Pvt. Limited, 2011. P.1-77

3. Images on "Extracellular accumulations"

4. Learning Videos on current topics: 

More on Osmosis:   https://www.youtube.com/channel/UCNI0qOojpkhsUtaQ4_2NUhQ.

5. Metodical developments for every topics are availibale in corresponding sections on Moodle by these link http://moodle.dma.dp.ua/ 

• Task:

1. Please, pass Initial MCQ Test.

2. On Workbook's page 10 carry out Microscopic Slide and Gross Specimen Descriptions:

• "Hyalinosis of the spleen capsula ("Ice-shugar spleen")";

• "Fatty infiltration of the heart".

3. On Workbook's page 11  in the "Individual Task " field, answer to the following Clinical Case: 

A morbidly obese 51-year-old woman dies from complications of heart disease. At autopsy, her heart weighs 600 gm (normal up to 300 gm) with all the chambers enlarged. Microscopically, there is increased fibrous connective tissue seen in the interstitium between myocardial fibers.  Beneath the epicardium can be seen adipocytes interdigitating with the myocardial fibers.

1.    Which term best describes the presence of the adipocytes in her myocardium?

2.   How is the described condition connected with a heart failure?

3.  Presume another severe complication that might occur at this patient, if the described condition is continuously developing in ventricular wall?

4.  Do you know the other pathological changes that could be founded in this case?

keep calm and wash your hands!