CELL DEATH. NECROSIS AND APOPTOSIS

Basics of thanatology. Necrosis. Clinical-morphological forms of the necrosis. Selective death of specialized cells: pathogen-induced apoptosis, selective death of cells, which is induced by immune system and cell destruction by activated complement

Questions for self-studying:

1. Cell death: definitions, terms and stages of development, morphological characteristics of regulated and accidental cellular death, their consequences.

2. Apoptosis. Pathogen-induced apoptosis: definitions, molecular mechanisms, term of development, microscopic manifestations, consequences.

3. Fundamentals of thanatology - the doctrine of death, its causes, mechanisms and features.

4. Birth and death. The death of the body of biological, social and medical terms: the idea of natural, violent death and death from disease (premature and sudden). Definition of intrauterine death.

5. Thanatogenesis. Structural mechanisms of cessation of vital organs activity during the natural course of the disease. The immediate effects of discontinuation of the heart, lungs, brain, kidneys and liver.

6. Biological death: the definition, immediate causes and timing of development in the natural course of the disease and in the sudden death of man. Early and late signs of biological death and death of a resuscitated patient. Morphological characteristics of corpse changes.

7. Ischemic-reperfusion injury: definitions, features of morphogenesis, morphological characteristics, consequences.

• Preparation materials:

1. Workbook, part I, pp. 14-15.

2. Sources:

1. Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins and Cotran Pathologic Basis of Disease. Ninth edition. Philadelphia, PA: Elsevier/Saunders, 2015.

2. Kumar, Vinay, Abul K Abbas, Jon C Aster, and Stanley L. 1915-2003 Robbins. Robbins Basic Pathology. Tenth Edition. Philadelphia, PA: Elsevier/Saunders, 2018.

3. Klatt, Edward C. Robbins and Cotran Atlas of Pathology. Third edition. Philadelphia, PA: Elsevier Saunders, 2015. 

4. Klatt, Edward C., and Vinay Kumar. Robbins and Cotran Review of Pathology. Fourth edi-tion. Philadelphia, PA: Elsevier Saunders, 2015.

5. Harsh Mohan. Textbook of Pathology. Seventh edition. Jaypee Brothers,Medical Publish-ers Pvt. Limited, 2014.

3. Images on "Cell Death. Necrosis and Apoptosis"

4. Learning Videos on current topics: 

More on Osmosis:   https://www.youtube.com/channel/UCNI0qOojpkhsUtaQ4_2NUhQ.

5. Metodical developments for every topics are availibale in corresponding sections on Moodle by these link http://moodle.dma.dp.ua/

• Task:

1. Please, pass Initial MCQ Test.

2. On Workbook's page 15 carry out Microscopic Slide and Gross Specimen Descriptions:

• "Myocardial infarction";

• "Kidney infarction".

3. On Workbook's page 15  in the "Individual Task #" field, explain your answer to MCQ's Tasks # 6. Why did you choose this answer as a right and exclude the rest?

4*. Perform a sketch of one slide presented on this page: "Cell Death. Necrosis and Apoptosis". Point on it the morphological changes that decribe selected pathological condition. Use the "For drawings, sketches" box on page 14 of the Workbook. 

keep calm and wash your hands!